The importance of proper food and nutrition has increased over time and the lack
of it has been linked with causes of many diseases. This has been a topic of
continuous research and one of the primary organs that is affected by nutrition
is the human brain. Obesity, acute high-fat food intake, poor early-life diet;
any one can trigger an
inflammatory response in peripheral immune cells and /or affect the blood–brain
interface and circulating molecules that control the state of brain. Blood
(carrying antibodies), lymphatic pathways and peripheral pro-inflammatory
chemicals can activate brain immune cells (microglia). Either sensitizing or
activating microglia may prompt synthesis of complex pro-inflammatory molecules
like interleukin-1beta (IL1-β), IL-6, and Tumour Necrosis Factor alpha (TNF- α)
in brain that are known to influence cognition and emotions. An increased
inflammation in these areas can affect normal functioning, resulting in memory
loss and/or depressive mood tendencies. By modulating peripheral and central
immune cell activity, polyunsaturated fatty acids (PUFA), flavonoids, tannic
acid, ellagitannin, and a positive early life environment (appropriate nutrition
and lack of severe stress or adversity) might avoid these unfavourable
consequences.
contact@researchthrive.com
+91
7737099220